Peptides selected for evaluation.

*Denotes peptides that could not be synthesized at high purity.IEDB = IEDB SMM predicted IC50 (nM).SY. = SYFPEITHI algorithm binding score.The cSNP alleles with the strongest association between gIR+ and cIR+ in the 57-patient cohort are shown. For each cSNP, gIR analysis was performed twice, once with the major allele considered the recipient allele (i.e. the allele that encodes the peptide presented by the recipient that is recognized by the donor T lymphocyte repertoire) and once with the minor allele considered the recipient allele. The cSNPs are ranked by decreasing statistical association of gIR+ and cIR+ for the recipient allele (column 2). The peptide containing the recipient allele-associated amino acid (shown in bold) that was predicted to bind most tightly to HLA-A0201 according the IEDB (SMM) and SYFPEITHI algorithms are shown in column 5 with IEDB and SYFPEITHI prediction scores in columns 6 and 7 respectively. The corresponding donor allele and donor peptide (i.e. the peptide associated with the donor's homozygous allele are shown in columns 8 and 9 respectively.