Liver function tests and fibrosis scores in a rural population in Africa

This is a dataset to support an analysis to estimate the prevalence and aetiology of liver disease in a rural population in Uganda.<br> The data were collected in 2011 from the Uganda General Population Cohort (GPC), based in Kyamulibwa, in the Kalungu district of South-Western Uganda, established in 1989 (partners: UK Medical Research Council, Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine). <br>We have assessed the prevalence of liver disease based on liver function tests (LFTs) and fibrosis scores, and estimated the burden of liver disease associated with alcohol, hepatitis b virus (HBV), HIV, and high or low body mass index.<br><br>The files included here are as follows:<br>1. Complete metadata underpinning the analysis, labelled 'GPC metadata table', provided as xls and csv files.<br>2. STROBE statement (STrengthening the Reporting of OBservational studies in Epidemiology) <br>3. A pdf document containing supplementary material (tables and figures), as follows:<br><b>Suppl Table 1:</b> Origin, reference ranges and clinical significance of liver function tests (LFTs) <br><b>Suppl Table 2:</b> Scores to estimate liver fibrosis, calculated from liver function tests<br><b>Suppl Table 3:</b> Description of characteristics of study participants with liver function test (LFT) results from the Ugandan General Population Cohort (N=8,099)<br><b>Suppl Table 4:</b> Median and inter-quartile range for each liver function test with the population divided by risk factors<br><b>Suppl Fig 1:</b> Distribution of liver function tests in Uganda General Population Cohort. <br><b>Suppl Fig 2:</b> Odds ratio for deranged ALT, AST, APRI, GPR and AST/ALT among participants grouped by sex and age.<br><b>Suppl Fig 3:</b> Proportion of Uganda General Population cohort reporting alcohol consumption among individuals with and without AST/ALT ratio &gt;2<br><b>Suppl Fig 4:</b> Proportion of Uganda General Population Cohort with elevated GGT, according to AST/ALT ratio. (A) males, with upper limit of normal GGT=61 (B) females, with upper limit of normal GGT=36. P-values by Fisher’s Exact Test<br><b>Suppl Fig 5: </b>Proportion of Uganda General Population Cohort with blood borne virus (BBV) infection, according to GPR score. P-value by Fisher’s Exact Test, showing significant enrichment of BBV infection among individuals with elevated GPR score &gt;0.32.<br><br>Ethics approval for this study was provided by:- the Science and Ethics committee of the UVRI (GC/127/12/11/06)- the Ugandan National Council for Science and Technology (HS870)- the East of England-Cambridge South (formerly Cambridgeshire 4) NHS Research Ethics Committee UK (11/H0303/5).All participants provided written informed consent.