Region-specific pathogenesis and dissipation of intraregional heterogeneity in cerebellar neurodegeneration

Heterogeneity and selective vulnerability are among the key features of the healthy and diseased brain. Cerebellum contains majority of brain cells, and is thought to be relatively uniform in structure. We explore heterogeneity in the context of healthy cerebellum and during selective vulnerability in cerebellar disease. Overall design: RNA-seq of cerebellar tissues in WT and SCA1 mice.