Corrias2008_GastricSlowWaveActivity

This a model from the article:
Quantitative cellular description of gastric slow wave activity.

Corrias A, Buist ML. Am J Physiol Gastrointest Liver Physiol
2008 Apr;294(4):G989-95 18276830
,
Abstract:

Interstitial cells of Cajal (ICC) are responsible for the spontaneous and
omnipresent electrical activity in the stomach. A quantitative description of
the intracellular processes whose coordinated activity is believed to generate
electrical slow waves has been developed and is presented here. In line with
recent experimental evidence, the model describes how the interplay between the
mitochondria and the endoplasmic reticulum in cycling intracellular Ca(2+)
provides the primary regulatory signal for the initiation of the slow wave. The
major ion channels that have been identified as influencing slow wave activity
have been modeled according to data obtained from isolated ICC. The model has
been validated by comparing the simulated profile of the slow waves with
experimental recordings and shows good correspondence in terms of frequency,
amplitude, and shape in both control and pharmacologically altered conditions.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Corrias A, Buist ML. (2008) - version02

The original CellML model was created by:
Corrias, Alberto,

[e-mail]
National University of Singapore
Division of BioEngineering
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