DKC1 downregulation by transient transfection of UT-SCC12A cells with siDKC1
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE207542
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We have investigated the functional effects of DKC1 downregulation in cSCC cells, and unveiled new roles for DKC1 in the metastatic process: metabolism and invasiveness. Transcriptional, proteomic and metabolomic analyses showed that reduced DKC1 levels in cSCC cells resulted in both an activation of the mevalonate pathway and the acquisition of an invasive phenotype. 6 samples were analysed (CTRL=3, DKCi=3)
创建时间:
2023-10-19



