Yeast Hsp90-dependent chromatin changes as monitored using DNase-Seq

We report the application of DNase-Seq (adapted from Hesselberth et al., 2009, as described in Zelin et al., 2012) to study the chromatin changes upon short Hsp90 depletion by exploiting temperature-sensitive allele G170D (Nathan and Lindquist, 1995)本研究报道了DNase测序（DNase-Seq）的应用。该方法改编自Hesselberth等人2009年的研究，并经Zelin等人2012年的研究详述，旨在通过利用温度敏感等位基因G170D（Nathan与Lindquist，1995），探究短期热休克蛋白90（Hsp90）耗尽所引发的染色质变化。