Tanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [human]. Tanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [human]

Purpose: To explore the mechanism of how Tan I inhibits malignant hematopoiesis at the gene expression level Methods: NB4 cells treated with DMSO or Tan I 10 μM were collected for RNA sequencing Results: We found that 376 genes were differentially expressed between DMSO and Tan I treatment in the NB4 cells (p value = 0.25) Conclusions: We identified MMP9 and ABCG2 as two possible downstream genes of Tan I’s effects on EZH2 Overall design: NB4 cells treated with DMSO or Tan I 10 μM