Vonoprazan pharmacokinetics and effects on gastric pH following administration to fed and fasted horses

This dataset supports research characterizing the pharmacokinetics of vonoprazan and investigating its effects on gastric pH in horses. The data set includes pharmacokinetic parameters for individual horses generated using non-compartmental pharmacokinetic analysis and the commercially available software program Phoenix WinNonlin (Certara, Princeton, NJ). Pharmacokinetic parameters generated from the pilot study (2 horses/group), assessing the effects of food on drug behavior (0.5 and 1 mg/kg oral doses), and a “full” study (n=6 horses) assessing the effects of a 1 mg/kg oral dose administered with food are included. A second data set includes gastric pH measurements as part of the “full” study (n=6 horses), both before and after vonoprazan administration (1 mg/kg oral dose). Measurements were collected via an engineered probe that was used to continuously measure intragastric pH for 12 hours before and 24 hours after each treatment. Sandhill Scientific software (Milwaukee, WI, USA) was used to determine the mean, maximum, and minimum pH. Calculations of the %t>pH4 were calculated at different time intervals. While the number of horses studied was limited, the results of the current study provide data that will be helpful in the design of further studies to assess the efficacy of vonoprazan in horses for the treatment of gastric ulcers.

Methods
The study was conducted as a randomised four‐way balanced crossover study. Six horses received vonoprazan (0.5 and 1 mg/kg), omeprazole (4 mg/kg), and water (60 mL). Blood samples were collected prior to and up to 72 h post‐administration. Plasma vonoprazan concentrations were measured using liquid chromatography–tandem mass spectrometry, and non‐compartmental and compartmental pharmacokinetic analyses were performed. Intragastric pH was continuously recorded 12 h before and 24 h after each treatment. The percentage of time pH remained above 4 was compared among treatments.