Life extension in Drosophila by feeding a drug
收藏PubMed Central2002-01-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC117392/
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资源简介：
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
提供机构：
National Academy of Sciences
创建时间：
2002-01-15
