Novel organoarsenical Z2 induces mitochondrial apoptosis in nasopharyngeal carcinoma through Hippo signaling pathway activation

Background: Nasopharyngeal carcinoma (NPC) is a highly aggressive malignancy with poor prognosis, especially in advanced stages, where treatment options remain limited. Although arsenic compounds have demonstrated anti-tumor potential in some hematological malignancies and solid tumors, their efficacy and mechanism in NPC remain poorly understood.