Regulator of G protein signaling contributes to the development and aflatoxin biosynthesis in Aspergillus flavus through the regulation of Ga activity.

purpose: to further gain insight into the effect of RGS proteins on aflatoxin biosynthesis in A. flavus NRRL3357. methods: two mutants ?rgsA and ?rgsE separately compared to WT were chose to conduct the analysis of transcriptomics. results: 1750 DEGs are found, including 720 upregulated genes and 1030 downregulated genes in (?rgsA vs WT); aflB, aflD, aflF, aflG, aflN, aflP, aflS from ?rgsE were transcriptionally reduced relative to ?rgsA in their expressions. Overall design: mRNA profiles of wild type (WT), ?rgsA and ?rgsE.