Single cell RNA sequencing for normal and Angiotensin ?-induced thoracic and abdominal aneurysmal aorta

Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta and weakness of the blood vessel walls . While the two diseases share several etiological similarities, there are also significant differences in population prevalence rate, genetic patterns and susceptibility genes. However, both TAAs and AAAs are complex, multifactorial and highly heterogeneous diseases, which greatly restricts our better knowledge of the two diseases. An improved knowledge of the cellular mechanism networks that trigger the development and succeeding expansion of aneurysms is critical to discovering innovative therapeutic targets. Overall design: This entry contains 10x Single-cell RNA-seq data of FACS sorted nucleated living cells from normal or 4-week Angiotensin ?-induced mouse thoracic and abdominal aorta.