Transcriptional Profiling of Lumbar Spinal Cord in a Rat Model of Bone Cancer Pain

Bone cancer pain (BCP), in which the majority is caused by metastasis from other cancer sites, is the most common type of chronic cancer pain. Bone cancer pain is developed accompanied by changes of numerous genes expression, from peripheral to central nervous system, which may account for this dysfunctional nociceptive perception. Although the pivotal role of lncRNA in neuropathic pain are well acknowledged, the involvement of lncRNA in bone cancer pain development are remain to be clarified. Thus, in the present study we performed transcriptome sequencing to explore changes in expression profiles of lncRNA and mRNA to provide a landscape of dysregulated lncRNA and mRNA in spinal cord of bone cancer pain.骨癌痛（Bone cancer pain, BCP）是临床最常见的慢性癌痛类型，其中绝大多数由其他恶性肿瘤的转移灶引发。骨癌痛的发生伴随外周至中枢神经系统的大量基因表达改变，此类改变或可解释该病症出现的伤害性感知异常。尽管长链非编码RNA（long non-coding RNA, lncRNA）在神经病理性疼痛中的关键作用已得到广泛认可，但该类分子在骨癌痛发生发展中的参与机制仍有待阐明。因此，本研究采用转录组测序技术，探究骨癌痛脊髓组织中长链非编码RNA与信使RNA（messenger RNA, mRNA）的表达谱变化，以期绘制骨癌痛脊髓组织中失调的lncRNA与mRNA的全景图谱。