Human epiphysis cerebri soft and calcified tissue by neurodegenerative diseases

The role of epiphysis cerebri (EC) in the development of neurodegenerative diseases is a focal point of our research. We recently found that EC with neuropathology has noticeable degenerative changes in its concrements and soft tissues. This research proposes to study 3D morphology of human EC, focusing on degeneration of calcification and soft tissue in Alzheimer disease (AD). Microtomography combined with phase contrast imaging at ID19 beamline ESRF will be used for a comparative analysis in control and AD groups. In addition, visualization of highly calcified tissue in 3D will allow us to gain a deeper understanding of the role of EC degeneration in AD.