Data from: Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants

This data respository contains data associated with a study to
characterize how missense mutations in PTPN11, the gene encoding the
protein tyrosine phosphatase SHP2, alter the protein-protein interactions
and localization. SHP2 has a catalytic domain that dephosphorylates
proteins and two phosphotyrosine-binding SH2 domains. One part of this
respository contains data that were used to map the sequence recognition
profiles of the two wild-type SH2 domains of SHP2. These sequence
recognition profiles were used to predict binding sites for each SH2
domain across the human proteome, and they are juxtaposed with the
proteomics data presented in the parent study. Another part of the
repository contains microscopy data examining the mitochondrial
localization of wild-type SHP2. A third part includes a structural model
of SHP2 bound to an interactor, PPIF, identified from proximity-labeling
proteomics experiments.