PRMT5/MEP50 crystal structure with MTA and phthalazinone fragment bound
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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PRMT5/MEP50 crystal structure with MTA and phthalazinone fragment bound Descriptor: 1,2-ETHANEDIOL, 4-(aminomethyl)phthalazin-1(2H)-one, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... Authors: Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Smith, C.R, Kulyk, S, Marx, M.A. Deposit date: 2021-08-31 Release date: 2022-01-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
创建时间：
2021-08-31
