Role of Deoxyribonucleic Acid Origami for Alleviating Kidney and Liver Injury in Diabetic Sepsis

Treating diabetic sepsis (DS) can be challenging because
of the
persistent infection of multiple organs. To address this complicated
pathological condition, it is necessary to develop advanced materials
and gain a better understanding of their roles. In this study, we
developed a two-dimensional planar material with a rectangular deoxyribonucleic
acid origami nanostructure (termed Rec-DON). Rec-DON was used to improve
liver and renal function in DS mice, as it preferentially accumulates
in these organs, and has superior anti-inflammatory activity and the
ability to scavenge reactive oxygen species. The role of Rec-DON in
the treatment of DS mice was investigated via quantitative proteomics.
This study revealed that Rec-DON can regulate key proteins located
primarily in the cytoplasm and mitochondrion, involved in protein
transport, antigen processing and presentation, and steroid metabolic
process, and can also bind to various proteins to restore liver and
renal function in DS mice. This study presented Rec-DON as a liver
and kidney targeting material and revealed its role in alleviating
multiorgan injury in DS.