Human PRMT5 in complex with AZ compound 28
收藏Protein Data Bank Japan2024-09-04 更新2026-04-19 收录
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Human PRMT5 in complex with AZ compound 28 Descriptor: (3~{S})-2-[(5-azanyl-6-fluoranyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-6-fluoranyl-1'-[(4-fluorophenyl)methyl]spiro[isoindole-3,3'-pyrrolidine]-1,2'-dione, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ... Authors: Debreczeni, J. Deposit date: 2024-04-09 Release date: 2024-08-14 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. J.Med.Chem., 67, 2024
创建时间：
2024-04-09
