Non-Synonymous Mitochondrial DNA and Amino Acid Alterations.

Notes: The nucleotide numbering system is based on the human mitochondrial revised Cambridge Reference Sequence. The tool on http://sift.jcvi.org was used to predict, whether an amino acid substitution affects protein function. The tool on http://genetics.bwh.harvard.edu/pph/ was used to predict possible impact of an amino acid substitution on the structure and function of a human protein. The bold base positions are recurrent alterations present in all CCA and HCC cell lines and hepatocyte cell line.