Third generation sequencing analysis detects significant differences in duodenal microbiome composition between functional dyspepsia patients and control subjects

Functional dyspepsia (FD) is a multifactorial disorder as its development may be based on several different pathophysiological mechanisms. Interaction of gut microbiome with the host has been proposed as a potential mechanism involved in the disease's pathogenesis. We aimed to characterize microbiome (DM) profiling on duodenal luminal contentof FD patients and compare it to that of controls (CG) and patients with irritable bowel syndrome (IBS).