Chiral Silver Complex-Catalyzed Diastereoselective and Enantioselective Michael Addition of 1‑Pyrroline-5-carboxylates to α‑Enones
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https://figshare.com/articles/dataset/Chiral_Silver_Complex-Catalyzed_Diastereoselective_and_Enantioselective_Michael_Addition_of_1_Pyrroline-5-carboxylates_to_Enones/5328403
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资源简介：
A AgOAc/ThioClickFerrophos
complex-catalyzed the highly diastereo-
and enantioselective reaction between 1-pyrroline-5-carboxylates (1) and acyclic α-enones (2) in MeOH, in
the presence of DBU, to give the single isomer Michael adducts (3) in high yields (up to 99%) with excellent enantioselectivies
(up to 99% ee). Subsequent reduction of the Michael adducts with sodium
cyanoborohydride successfully produced the fused pyrrolizidine ester
as an almost pure single stereoisomer.
创建时间：
2017-08-21
