Microbiomics combined metabolomics reveals Akkermansia modulating chicken gut microenvironment to protect from gamma coronavirus infection

In this study, we comprehensively investigated the influence of gut microbiota on gamma coronavirus replication in chickens. Using multi-omics approaches, we systematically examined microbial, viral and metabolic differences among adult chickens, young chickens and young chickens subjected to fecal microbiota transplantation from adults, establishing a mechanistic basis for the observed enhanced resistance to infectious bronchitis virus (IBV) in adult chickens