RNA binding protein PCBP2 regulates pancreatic β cell function and adaptation to glucose

Glucose plays a key role in shaping pancreatic β cell function. Thus, deciphering the mechanisms by which this nutrient stimulates β cells holds therapeutic promise for combating β cell failure in type 2 diabetes (T2D). β cells respond to hyperglycemia in part by rewiring their mRNA metabolism, yet the factors governing these changes remain poorly understood. Here, we interrogate the transcriptomes of control β cells and mutant β cells lacking the RNA binding protein PCBP incubated with low or high glucose for 72 hours. RNASeq was performed in control and Pcbp2 null β cells exposed to low or high glucose for 72 hours.