Expression pattern of genes in condyloma acuminata treated with Clinacanthus nutans Lindau cream versus podophyllin

Data reported on the efficacy and therapeutic mechanism of <i>Clinacanthus nutans </i>Lindau cream <i>(C. nutans) </i>and podophyllin in condyloma acuminata (CA). Using a randomized block design, six patients were treated with <i>C. nutans</i>and podophyllin for four weeks. Efficacy of drugs wasassessed by size reduction of the warts and HPV viral load quantification using droplet digital PCR.<i></i>The gene expression profiling of CA was analyzed using NanoString Technology.<b></b>After the podophyllin and <i>C. nutans</i>treatment, the CA lesion sizes were reduced to 97.0% and 84.4% clearance, respectively. HPV viral loads were reduced to 74.0% after podophyllin treatment and 46.6% with <i>C. nutans</i>.The gene expression pattern of immune profiling showed 23 genes were significantly differentially expressed by podophyllin while 2 genes were remarkably expressed by <i>C. nutans. </i>In inflammatory profiling, 108 genes were highly expressed by podophyllin, but none of genes were observed to change expression by <i>C. nutans.</i>These results suggested that podophyllin may reduce the HPV infection through a mechanism related to pro-inflammatory response. Unlike podophyllin, <i>C. nutans</i>was found to suppress the HPV infection through mechanism related to the activation of immune response. This is the first study to report in a novel therapeutic mechanism of podophyllin and <i>C. nutans</i>treatments, and the highlight that <i>C. nutans </i>can be an alternative medicine for CA treatment.<i> </i>