Corrupted DNA-binding specificity and ectopic transcription underpin dominant neomorphic mutations in KLF/SP transcription factors

Study of mutations in the DNA-binding domain Overall design: ChIP-seq of CDA(E339K)-KLF1 in erythroid cell lines. 4sU-RNA-seq before and after induction of CDA(E339K)-KLF1 in erythroid cell lines.