N-myristoylation of eNOS

The enzymes glycylpeptide N-tetradecanoyltransferase 1 and 2 (NMT1/2) are inferred to mediate the transfer of a myristoyl (MYS) group from myristoyl-CoA to the glycine (Gly) residue exposed by removal of the aminoterminal methionine residue of nascent NOS3 (eNOS, Nitric oxide synthase 3) (Liu & Sessa 1994). The ability of NMT1/2 to mediate N-myristoylation of a wide array of proteins is well established (Gordon et al. 1991), although their activity on NMT1/2 has not been studied.

甘氨酰肽N-十四烷酰转移酶1和2（NMT1/2）被认为介导了月桂酰（MYS）基团从月桂酰辅酶A转移到新生一氧化氮合酶3（eNOS，一氧化氮合酶3）去氨基末端甲硫氨酸残基暴露的甘氨酸（Gly）残基上（Liu & Sessa 1994）。NMT1/2介导多种蛋白质N-月桂酰化的能力已得到充分证实（Gordon et al. 1991），尽管其对NMT1/2的活性尚未进行研究。