Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] polyphenol extract (OPE) promote osteoblastic differentiation in MC3T3-E1 cells and reduce ovariectomy-induced bone loss in rats via the calcium/AMPK signaling pathway

Osteoporosis (OP) is a systemic bone disease associated with aging and imbalance in bone metabolism. In this study, the osteoprotective activity of Chinese dwarf cherry (Cerasus humilis) polyphenol extract (OPE) was characterized in vitro and in vivo, and the osteoprotective mechanism was studied.