five

ChIP-seq of the binding DNA by NS5

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https://www.ncbi.nlm.nih.gov/sra/SRP304122
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The ChIP-seq and RNA-seq data provide evidence that ZIKV-NS5 binds to the gene body of the key neuro-factors and then inhibits their transcription, thus disrupting the neurogenesis of human NPCs. Overall design: Overexpressed ZIKV-NS5 in hNPCs and collected cells 48 hours post infection by lentivirus. And the input was set as the control.
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2022-01-28
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