Expression data of LN229 cells treated with 23 Pa compressive solid stress (CSS) or no CSS

Glioblastoma ( GBM) is an astrocytic brain tumor with median survival times of < 15 months, primarily as a result of high infiltrative potential and development of resistance to therapy (i.e., surgical resection, chemoradiotherapy). A prominent feature of the GBM microenvironment is compressive solid stress (CSS) caused by uninhibited tumor growth within the confined skull. We used microarrays to explore the gene expression of LN229 cells treated with 23 Pa CSS as compared to no CSS. The purpose is to detect the up-regulated genes induced by CSS. LN229 cells were treated either under 23 Pa CSS or no CSS for 18 hrs and then extracted for RNA. RNA samples were then purified and processed on Affymetrix Human Transcriptome Array 2.0 chip.