CBFb-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia [5C]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109764
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We demonstrate that CBFb-SMMHCmaintains leukemia viability by inhibiting RUNX1 repression of MYC expression. Upon pharmacologic inhibition of CBF-SMMHC/RUNX1 binding, RUNX1 increases its association with three MYC distal downstream enhancers and represses MYC expression. 5C Chromosome Conformation Capture Carbon Copy
创建时间：
2019-03-21
