General overview of human-worm complex I subunit and subcomplex homology.

Notes:Two strains were studied for homologues of two Iλ subunits, NDUFS2 and NDUFA2 - see Table 1 notes for details.
**Iγ consists of “breakthrough fractions” in the purification of subcomplexes Iα and Iβ from bovine heart mitochondria, but only KFY1.
Extensive conservation is apparent between human and C. elegans complex I composition, as broken down by either genome of origin or subcomplex. ‘Percent conserved’ indicates the number of human complex I subunits in each group for which a C. elegans homologue can be identified, rather than the extent of similarity between specific subunits. *, two strains each were studied for homologues of two 1λ subunits, NDUFS2 and NDUFA2, per details in Table 1 legend. **, only KFY1 is found in no other fraction except 1γ. *** MLRQ is not localized to any subcomplex (4).