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Mouse ES cell line single cell transcriptome changes upon replication stress

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NIAID Data Ecosystem2026-04-25 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP120761
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To understand whether activation of ATR-dependent replication stress response could result in global transcriptional alterations similar to that of 2C-like cells, we performed single cell whole transcriptional profiling on the E14 mouse ESC line upon aphidicolin treatment or aphidicolin + ATR inhibitor treatment. For comparison we also did single cell whole transcriptome profiling of the E14 cell line without any treatment.
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2020-10-05
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