METHODS FOR CONSTRUCTING HIGH-ACTIVITY T-CELLS FOR IMMUNOTHERAPY
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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FIELD: immunology. SUBSTANCE: disclosed is a method for producing primary T-cells， involving genetic modification of T-cells using low-boiling endonucleases， particularly TALE-nuclease， capable of selectively inactivating a gene， which encodes an immune control point protein， and a gene which codes a T-cell receptor component (TCR)， and introduction into T-cells of a nucleic acid coding a chimeric antigenic antigen receptor to CD19. What is described is a T cell obtained in such a way， containing it a pharmaceutical composition and a method of treating cancer. EFFECT: present invention can be used in adoptive immunotherapy. 17 cl， 31 dwg， 15 tbl， 5 ex
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国家林业和草原科学数据中心
创建时间：
2023-02-12
