Genomic epidemiological analysis of mcr-1-harboring Escherichia coli collected from livestock setting in Vietnam

Livestock has been implicated as a reservoir for antimicrobial resistance (AMR) gens that can spread to humans when antimicrobials were used in food animals to treat clinical diseases and prevent and control common disease events. In Vietnam, mcr-1-harboring Escherichia coli (MCRPEC) strains have been isolated from humans, animals (chickens, pigs, and dogs) feces, flies, foods, and environmental (rain, well, and irrigation water) in communities and from clinical specimens in hospitals. The relationship between levels of AMR in livestock and its occurrence in humans is complex and belongs to many factors. Therefore, we conducted a whole genome sequencing technique to analyze the molecular epidemiological characteristics, history, and relatedness of 50 MCRPEC isolates obtained from different reservoirs in the farms and markets in Ha Nam province, Vietnam in 2019.