circVAR

Circular RNAs (circRNAs), the 3' and 5' ends of which are covalently linked, are a kind of widely distributed and abundant RNAs found in eukaryotic organisms in recent years. They could play as sponges for regulating microRNAs and RNA binding proteins. Our circVAR database aims to provide resources for circRNA-related genetic variants in healthy and diseased populations.环状RNA（circular RNAs，circRNAs）是一类近年在真核生物中被发现的、广泛分布且含量丰富的RNA分子，其3'端与5'端通过共价键相连。这类RNA可充当分子海绵，调控微小RNA（microRNAs）与RNA结合蛋白的活性。我们搭建的circVAR数据库旨在为健康与疾病人群中与环状RNA相关的遗传变异提供数据资源。

搜集汇总

背景与挑战

背景概述

circVAR是一个专注于人类环状RNA（circRNA）的免费在线遗传资源数据库，旨在为健康与疾病人群提供circRNA相关遗传变异的全面数据。该数据库整合了来自circBase、CircNet和circRNAdb等多个来源的circRNA信息，并支持快速搜索和批量下载遗传变异数据，涵盖GWAS、clinVAR、COSMIC和1000基因组项目等数据源。