RNAseq data Male and Female Het vs Wt

Epilepsy is a common disorder; however, the pathophysiology of epileptogenesis and the molecular mechanisms underlying sex differences in epilepsy remain unclear. We observed blood-brain barrier dysfunction in both sexes prior to seizure onset, which was exacerbated in males once seizures were established. The initial male response of gliosis and CREB signaling likely led to maladaptive effects after seizures, while females initially activated energy enhancing pathways and switched to a more neuroprotective metabolic program in response to increased neuronal excitability. These findings reveal epileptogenic processes shared between the sexes, as well as sexually dimorphic responses that lead to increased seizure resilience in females.