Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression (Agilent circRNA data set)

To explore the molecular mechanisms underlying circRNA role in prostate carcinogenesis and progression of PCa, we first used circular RNA microarrays to acquire circRNA profiles in PCa tissues. Five pairs of samples were taken from the two different areas, i.e., high-grade PCa (Gleason>8) and low-grade PCa (Gleason< 6), within the same PCa sample Microarray hybridization analysis of circRNA expression in five pairs of PCa samples with areas of high grade disease (Gleason>8) or areas of low grade (Gleason<6) was performed according to the manufacturer’s protocol (Arraystar, Inc., Rockville, MD, USA).