Regulation of resolution indices: lidocaine vs. isoflurane

Resolution indices are quantitatively defined as: (i) Magnitude (Ψmax, Tmax)–The time point (Tmax), following challenge or injury, when neutrophil numbers in tissues or exudates reach maximum (Ψmax); (ii) Duration (R50, T50)–The time point (T50) when the neutrophil numbers reduce to 50% of Ψmax (R50); (iii) Resolution Interval (Ri)–The time interval from the maximum neutrophil infiltration time point (Ψmax) to 50% reduction point (R50) [i.e. T50−Tmax]. Lidocaine treatment enhanced the magnitude (Ψmax) and delayed the onset of resolution (Tmax). In contrast, isoflurane reduced magnitude (Ψmax) and shortened resolution interval (Ri). See Figure S1 for further details and calculations.