MicroRNA-based prognostic model for early-stage oral cancer patients

The aim of our study is to develop a miRNA marker panel prognostic of 5-year survival in early-stage OSCC patients. We assessed differential expression of miRNAs genome-wide via deep sequencing in 100 tumor tissue samples. We also attempted to identify deregulated miRNA expression signatures that may serve as the prognostic markers. Overall design: Identify miRNAs differentially expressed in the poor prognosis group (those who had recurrence and/or died of cancer) compared to the favoarble prognosis group (those who had 5-year cancer-free survival)