Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms by enhancing NAMPT activity in male mice

NIAID Data Ecosystem2026-03-14 收录

抗衰老干预

NAD+代谢

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA910147 数据链接链接失效反馈

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low dose nicotine boots NAD generation and increase nampt activity

创建时间：

2022-12-08

Mitochondria-targeted partial inhibiton of complex I increase health and lifespan in aged male and female mice.. Mitochondria-targeted partial inhibiton of complex I increase health and lifespan in aged male and female mice.

抗衰老干预

线粒体转录组

We performed next-generation RNA sequencing (RNA-seq) using brain and fat tissue from 26 months old vehicle and CP2-treated (wild-type) WT mice. Overall design: mRNA profiles of 26 months old Veh-trea

NIAID Data Ecosystem60

A role for Pak2 kinase in cellular senescence and organismal aging

细胞衰老机制

抗衰老干预

Cellular senescence is an irreversible cell growth arrest state linked to loss of tissue function and aging in mammals. The cellular transition from proliferation to senescence is marked by increased

NIAID Data Ecosystem30

The slit2 induces rejuveation in mid old cells.

细胞再生机制

抗衰老干预

The slit2 induces rejuveation in mid old cells such as reduces inflammation and inhibite cell cycle arrest. The mid old cells were treated with Slit2(100ng/ml) for 2days and cells harvested and extrac

NIAID Data Ecosystem10

Delaying aging and enhancing repair of the aged CNS myelin by β-NMN requires SIRT2

髓鞘修复机制

抗衰老干预

Delaying aging and enhancing repair of the aged CNS myelin by β-NMN requires SIRT2

integrated proteome resources40

Table_1_Effectiveness of a mHealth platform-based lifestyle integrated multicomponent exercise (PF-Life) program to reverse pre-frailty in community-dwelling older adults: a randomized controlled trial study protocol.docx

抗衰老干预

移动健康运动疗法

BackgroundPre-frailty represents an ideal window of opportunity to potentially prevent frailty and disability. Early and effective interventions to delay or reverse pre-frailty are public health imper

NIAID Data Ecosystem10

Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms by enhancing NAMPT activity in male mice

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