RNAseq profiling of skin samples from wild type and RIPK1E-KO mice

Keratinocyte-specific RIPK1 deficiency causes skin inflammation due to ZBP1-induced necroptosis. RNA-Seq analysis of the skin from wild type and RIK1E-KO mice was performed to examine how RIPK1 deficiency affects the expression of mRNAs as well as endogenous retroelement-derived transcripts. RNAseq was performed in RNA from either epidermal or total skin samples from wildtype and RIK1E-KO mice that were untreated or treated with reverse transcriptase inhibitors.