Plasma miRNA as potential biomarkers for Alzheimer's Disease

The deregulation of microRNA (miRNA) might be potential biomarkers for Alzheimer's Disease (AD). In this study, we aim to investigate the miRNA profiles of AD in Malaysian AD patients. Small RNA sequencing was performed in order to obtain the miRNA profiles from the peripheral plasma of AD patients and normal controls. Differential expression analysis was performed to identify the dysregulated miRNAs. Three miRNAs that are relevant with AD were identified. The functions of these miRNAs were found to be related with oxidative phosphorylation, mitochondrial dysfunction and calcium-mediated signalling, which contributed to AD pathogenesis. This study supports evidence that the miRNA expression changes in AD and indicates the need for further study in this area. Overall design: Small RNA sequencing was performed on 7 AD patient and 4 normal control. The miRNA profiles was extracted using NEXTflex Illumina Small RNA Sequencing Kit v3. Grant ID: FRGS/1/2019/SKK06/UM/02/5 Grant Title: A Machine Learning Integrated Framework for Investigating Potential Biomarkers in Alzheimer's Disease Funding source: Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education Malaysia.