Single-cell RNA sequencing reveals the ability to metastasize of tumor in human hypopharygeal squamous cell carcinoma and lymphatic metastasis

Human hypopharygeal squamous cell carcinoma (HSCC) is a common head and neck cancer with a poor prognosis in advanced stages. Determining genes associated with transferring in HSCC could provide new targets and therapeutic strategies. We performed single-cell RNA sequencing of hypopharyngeal carcinoma and lymphoid metastases from five patients with hypopharyngeal squamous cell carcinoma. Overall design: Examination of the expression of cells and genes of hypopharyngeal carcinoma and lymphoid metastases from five patients with hypopharyngeal squamous cell carcinoma