five

Induced-pluripotent stem-derived vascular endothelial cells in Down syndrome

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE203257
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To investigate the physiological characteristics of endothelial cells (EC) harboring trisomy 21 (T21), we establised isogenic pairs of T21-iPSCs and corrected disomy 21 (cDi21)-iPSCs We then performed gene expression profiling analysis using data obtained from RNA-seq of 5 different iPSC-derived ECs. Comparative gene expression profiling analysis of RNA-seq data for two independent iPSC-derived EC lines of patients with DS (T21 and T21’), two independent iPSC-derived EC lines of HC_1 and HC_2, and an isogenic iPSC-derived EC line of cDi21.
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2022-05-20
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