Community-based Referral for Tuberculosis Preventive Therapy is Effective for Treatment Completion

We compared two strategies for initiating TB preventive therapy in a high HIV and TB prevalence community in rural South Africa. We demonstrate that a community-based approach to identifying and referring TPT-eligible PWH resulted in a 10% absolute higher completion rate and significantly better adherence compared to those PWH who were already engaged in care. This is among the first studies to successfully leverage a community-based approach for implementing TPT for PWH.