Ru-MACHO-Catalyzed Direct Inter/Intramolecular Macrocyclization of Alcohols and Ketones

Herein
we describe a new approach for end-to-end cyclization to
construct macrocycles through the inter/intramolecular dehydrogenative
coupling of alcohols and ketones in the presence of a Ru-MACHO catalyst.
This method is highly atom economical and sustainable and can be used
for many substrates. Additionally, this method results in the generation
of only water as the byproduct. Moreover, in this approach, high dilution
of the reactants is crucial for cyclization and high-yield macrocycle
synthesis.