Integrative analysis of hepatic microRNA and mRNA to identify potential biological pathways associated with monocrotaline-induced liver injury in mice. Mus musculus

In this study, the analysis of miRNA and mRNA expression profiles was used to identify the potential engaged biological signaling pathways involved in Monocrotaline-induced liver injury. There were total 35 hepatic miRNAs differentially expressed in mice treated with Monocrotaline (both 270 mg/kg and 330 mg/kg) Overall design: [miRNA] In the study presented here, 9 liver samples from 3 groups (control group,270 mg/kg MCT group and 330mg/kg MCT group) were collected, each group contained 3 replicates, and were used to acquire expression profiles of a total of 1,177 unique miRNAs. [mRNA] In the study presented here, 9 liver samples from 3 groups(control group,270 mg/kg MCT group and 330mg/kg MCT group)were collected, each group contained 3 replicates, and were used to acquire expression profiles of a total of 18,816 genes.