Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α‑Amidation of β‑Keto Esters
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https://figshare.com/articles/dataset/Modular_Tuning_of_Electrophilic_Reactivity_of_Iridium_Nitrenoids_for_the_Intermolecular_Selective_Amidation_of_Keto_Esters/12609457
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资源简介：
We
report herein an Ir-catalyzed intermolecular amino group transfer
to β-keto esters (amides) to access α-aminocarbonyl products
with excellent chemoselectivity. The key strategy was to engineer
electrophilicity of the putative Ir-nitrenoids by tuning electronic
property of the κ2-N,O chelating ligands, thus facilitating nucleophilic addition of enol
π-bonds of 1,3-dicarbonyl substrates.
创建时间：
2020-06-30
