Mode of action studies for a novel anti-leishmania compound
收藏NIAID Data Ecosystem2026-03-10 收录
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https://www.omicsdi.org/dataset/pride/PXD009711
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资源简介：
We describe the development of a novel anti-leishmanial drug-like chemical series based on a pyrazolopyrimidine scaffold. The leading compound is efficacious in a mouse model of visceral leishmaniasis, and has suitable physicochemical, pharmacokinetic and toxicological properties for further development and has been declared a preclinical candidate. Detailed mode of action studies indicate that compounds from this series act principally by inhibiting the parasite protein kinases.
创建时间：
2018-11-30
