Crystal Structure of BACE with Compound 14g
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Crystal Structure of BACE with Compound 14g Descriptor: 4-{[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxido-2-thia-1,3,8-triazaspiro[4.5]dec-8-yl]methyl}-2-(propan-2-yloxy)phenol, Beta-secretase 1, ZINC ION Authors: Vajdos, F.F, Varghese, A.H. Deposit date: 2012-06-15 Release date: 2012-10-03 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Spirocyclic sulfamides as beta-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors. J.Med.Chem., 55, 2012
创建时间：
2012-06-15
